PT  - JOURNAL ARTICLE
AU  - Andrew McPherson
AU  - Sohrab Shah
AU  - S. Cenk Sahinalp
TI  - deStruct: Accurate Rearrangement Detection using Breakpoint Specific Realignment
AID  - 10.1101/117523
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 117523
4099  - http://biorxiv.org/content/early/2017/03/18/117523.short
4100  - http://biorxiv.org/content/early/2017/03/18/117523.full
AB  - We propose that a breakpoint specific alignment procedure would improve breakpoint prediction. Our method, deStruct, uses multiple stages of realignment and clustering to progressively refine breakpoint prediction quality and accuracy. We show using simulated data that deStruct predicts breakpoints with higher sensitivity and specificity than existing breakpoint prediction tools.