RT Journal Article SR Electronic T1 deStruct: Accurate Rearrangement Detection using Breakpoint Specific Realignment JF bioRxiv FD Cold Spring Harbor Laboratory SP 117523 DO 10.1101/117523 A1 Andrew McPherson A1 Sohrab Shah A1 S. Cenk Sahinalp YR 2017 UL http://biorxiv.org/content/early/2017/03/18/117523.abstract AB We propose that a breakpoint specific alignment procedure would improve breakpoint prediction. Our method, deStruct, uses multiple stages of realignment and clustering to progressively refine breakpoint prediction quality and accuracy. We show using simulated data that deStruct predicts breakpoints with higher sensitivity and specificity than existing breakpoint prediction tools.