RT Journal Article
SR Electronic
T1 Eyes closed or Eyes open? Exploring the alpha desynchronization hypothesis in resting state functional connectivity networks with intracranial EEG
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 118174
DO 10.1101/118174
A1 Jaime Gómez-Ramírez
A1 Shelagh Freedman
A1 Diego Mateos
A1 José Luis Pérez-Velázquez
A1 Taufik Valiante
YR 2017
UL http://biorxiv.org/content/early/2017/03/18/118174.abstract
AB This paper addresses a fundamental question, are eyes closed and eyes open resting states equivalent baseline conditions, or do they have consistently different electrophysiological signatures? We compare the functional connectivity patterns in an eyes closed resting state with an eyes open resting state, and show that functional connectivity in the alpha band decreases in the eyes open condition compared to eyes closed. This "alpha desynchronization " or reduction in the number of connections from eyes closed to eyes open, is here, for the first time, studied with intracranial recordings. We provide two calculations of the wiring cost, local and mesoscopic, defined in terms of the distance between the electrodes and the likelihood that they are functionally connected. We find that, in agreement with the "alpha desynchronization" hypothesis, the local wiring cost decreases going from eyes closed to eyes open. However, when the wiring cost calculation takes into account the connectivity pattern, the wiring cost variation from eyes closed to eyes open is not as consistent and shows regional specificity. The wiring cost measure defined here, provides a new avenue for understanding the electrophysiology of resting state.