PT  - JOURNAL ARTICLE
AU  - Alan L. Hutchison
AU  - Aaron R. Dinner
TI  - Correcting for Dependent P-values in Rhythm Detection
AID  - 10.1101/118547
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 118547
4099  - http://biorxiv.org/content/early/2017/03/20/118547.short
4100  - http://biorxiv.org/content/early/2017/03/20/118547.full
AB  - There is much interest in using genome-wide expression time series to identify circadian genes. Several methods have been developed to test for rhythmicity in sparsely sampled time series typical of such measurements. Because these methods are statistical in nature, they rely on estimating the probabilities that patterns arise by chance (i.e., p-values). Here we show that leading methods implicitly make inappropriate assumptions of independence when estimating p-values. We show how to correct for the dependence to obtain accurate estimates for statistical significance during rhythm detection.