PT  - JOURNAL ARTICLE
AU  - Ann-Gerd Thorsell
AU  - Herwig Schüler
TI  - Selectivity profile of the poly(ADP-ribose) polymerase (PARP) inhibitor, A-966492
AID  - 10.1101/119818
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 119818
4099  - http://biorxiv.org/content/early/2017/03/23/119818.short
4100  - http://biorxiv.org/content/early/2017/03/23/119818.full
AB  - Among the clinical inhibitors of poly(ADP-ribose) polymerases (PARPs) and the commonly used PARP research tool compounds, veliparib and niraparib were recently identified as the most selective inhibitors of PARP1 and PARP2. We characterized the potency of A-966492, a PARP inhibitor with a chemical structure similar to veliparib and niraparib, in in vitro inhibition experiments of six PARP family enzymes. We find that the selectivity of A-966492 for PARP1 and PARP2 is intermediate between veliparib and niraparib.