PT - JOURNAL ARTICLE AU - Darren Price AU - Matthew J. Brookes AU - Elizabeth B. Liddle AU - Peter F. Liddle AU - Lena Palaniyappan AU - Peter G. Morris TI - Modelling Theta-Band Connectivity Between Occipital and Frontal Lobes: A Methodological MEG Study AID - 10.1101/123471 DP - 2017 Jan 01 TA - bioRxiv PG - 123471 4099 - http://biorxiv.org/content/early/2017/04/03/123471.short 4100 - http://biorxiv.org/content/early/2017/04/03/123471.full AB - Measuring functional connectivity between cortical regions of the human brain has become an important area of research. Modern theory suggests that brain networks exhibit non-stationarity, constantly forming and reforming depending on task demands. A robust means of determining effective connectivity in the short-lived neural responses that occur in event related paradigms would allow the investigation of event related cortico-cortical dynamics. We present such a mathematical model of wave propagation, motivated by current neuroscience literature, and demonstrate the utility of the method in a clinical sample of schizophrenia patients. MEG data were acquired in 10 patients with schizophrenia and 12 healthy controls during a relevance modulation task. Data were filtered into the theta band (4-8Hz) and source localised using a beamformer. The model was implemented using Fourier analysis methods which uncovered an event related travelling wave moving from the visual to frontal cortices. The model was validated using Monte Carlo phase randomisation and compared with another plausible model of wave propagation in the cortex. Results from the clinical sample revealed that wave speed was modulated by task condition and patients were found to have less difference between conditions (ANOVA revealing a significant interaction between group and condition, p<0.05). In conclusion, our method provides a simple and robust means to investigate event related cortico-cortical brain dynamics in individuals and groups in the task positive state.