TY - JOUR T1 - Polygenic prediction of the phenome, across ancestry, in emerging adulthood JF - bioRxiv DO - 10.1101/124651 SP - 124651 AU - Anna R. Docherty AU - Arden Moscati AU - Danielle Dick AU - Jeanne E. Savage AU - Jessica E. Salvatore AU - Megan Cooke AU - Fazil Aliev AU - Ashlee A. Moore AU - Alexis C. Edwards AU - Brien P. Riley AU - Daniel E. Adkins AU - Roseann Peterson AU - Bradley T. Webb AU - Silviu A. Bacanu AU - Kenneth S. Kendler Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/04/06/124651.abstract N2 - Background Identifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology. College-age individuals are under-represented in genomic analyses thus far, and the majority of work has focused on clinical disorder or cognitive abilities rather than normal-range behavioral outcomes.Methods This study examined a sample of emerging adults 18-22 years of age (N = 5,947) to construct an atlas of polygenic risk for 33 traits predicting real-world outcomes. Twenty-eight hypotheses were tested based on the previous literature on samples of European ancestry, and the availability of rich assessment data allowed for polygenic predictions across 55 psychological and medical phenotypes.Results Polygenic risk for schizophrenia in emerging adults predicted anxiety, depression, nicotine use, trauma, and family history of psychological disorders. Polygenic risk for neuroticism predicted anxiety, depression, phobia, panic, neuroticism, and risk for cardiovascular disease.Conclusions These results calcify unique links between genetic risk for schizophrenia, neuroticism, substance use, and important health factors in healthy early adulthood, and demonstrate cross-ancestry replication of these genetic relationships. ER -