PT - JOURNAL ARTICLE AU - Xiao Wang AU - Yan Hao AU - Seth H. Weinberg AU - Gregory D. Smith TI - Ca<sup>2+</sup>-activation kinetics modulate successive puff/spark amplitude, duration and inter-event-interval correlations in a Langevin model of stochastic Ca<sup>2+</sup> release AID - 10.1101/014431 DP - 2015 Jan 01 TA - bioRxiv PG - 014431 4099 - http://biorxiv.org/content/early/2015/01/27/014431.short 4100 - http://biorxiv.org/content/early/2015/01/27/014431.full AB - Through theoretical analysis of the statistics of stochastic calcium (Ca2+) release (i.e., the amplitude, duration and inter-event interval of simulated Ca2+ puffs and sparks), we show that a Langevin description of the collective gating of Ca2+ channels may be a good approximation to the corresponding Markov chain model when the number of Ca2+ channels per Ca2+ release unit (CaRU) is in the physiological range. The Langevin description of stochastic Ca2+ release facilitates our investigation of correlations between successive puff/spark amplitudes, durations and inter-spark intervals, and how such puff/spark statistics depend on the number of channels per release site and the kinetics of Ca2+-mediated inactivation of open channels. When Ca2+ inactivation/de-inactivation rates are intermediate—i.e., the termination of Ca2+ puff/sparks is caused by the recruitment of inactivated channels—the correlation between successive puff/spark amplitudes is negative, while the correlations between puff/spark amplitudes and the duration of the preceding or subsequent inter-spark interval are positive. These correlations are significantly reduced when inactivation/deinactivation rates are extreme (slow or fast) and puff/sparks terminate via stochastic attrition.