@article {Rosen125542, author = {Yohei Rosen and Jordan Eizenga and Benedict Paten}, title = {Describing the Local Structure of Sequence Graphs}, elocation-id = {125542}, year = {2017}, doi = {10.1101/125542}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Analysis of genetic variation using graph structures is an emerging paradigm of genomics. However, defining genetic sites on sequence graphs remains an open problem. Paten{\textquoteright}s invention of the ultra-bubble and snarl, special subgraphs of sequence graphs which can identified with efficient algorithms, represents important first step to segregating graphs into genetic sites. We extend the theory of ultrabubbles to a special subclass where every detail of the ultrabubble can be described in a series and parallel arrangement of genetic sites. We furthermore introduce the concept of bundle structures, which allows us to recognize the graph motifs created by additional combinations of variation in the graph, including but not limited to runs of abutting single nucleotide variants. We demonstrate linear-time identification of bundles in a bidirected graph. These two advances build on initial work on ultrabubbles in bidirected graphs, and define a more granular concept of genetic site.}, URL = {https://www.biorxiv.org/content/early/2017/04/13/125542}, eprint = {https://www.biorxiv.org/content/early/2017/04/13/125542.full.pdf}, journal = {bioRxiv} }