@article {Huang128975, author = {Hailiang Huang and Priya Duggal and Chloe L. Thio and Rachel Latanich and James J. Goedert and Alessandra Mangia and Andrea L. Cox and Gregory D. Kirk and Shruti Mehta and Joel N. Blankson and Jasneet Aneja and Laurent Alric and Sharyne M. Donfield and Matthew E. Cramp and Salim I. Khakoo and Leslie H. Tobler and Michael Busch and Graeme J. Alexander and Hugo R. Rosen and Brian R. Edlin and Georg M. Lauer and David L. Thomas and Mark J. Daly and Raymond T. Chung and Arthur Y. Kim}, title = {Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection}, elocation-id = {128975}, year = {2017}, doi = {10.1101/128975}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Approximately three quarters of acute HCV infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using Immunochip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL41,2 and MHC regions, with spontaneous clearance in the European population. We further fine-mapped the MHC association to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in the MHC locus might be significantly stronger for virus subtype 1a than 1b, suggesting that viral subtype may have influenced the genetic mechanism underlying the clearance of HCV.}, URL = {https://www.biorxiv.org/content/early/2017/04/20/128975}, eprint = {https://www.biorxiv.org/content/early/2017/04/20/128975.full.pdf}, journal = {bioRxiv} }