RT Journal Article
SR Electronic
T1 Differential Evolution Approach to Detect Recent Admixture
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 015446
DO 10.1101/015446
A1 Konstantin Kozlov
A1 Dmitry Chebotarov
A1 Mehedi Hassan
A1 Martin Triska
A1 Petr Triska
A1 Pavel Flegontov
A1 Tatiana Tatarinova
YR 2015
UL http://biorxiv.org/content/early/2015/02/19/015446.abstract
AB The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual’s knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.