PT  - JOURNAL ARTICLE
AU  - Phoebe S. Tsoi
AU  - Kyoungjae J. Choi
AU  - Paul G. Leonard
AU  - Antons Sizovs
AU  - Mahdi Muhammad Moosa
AU  - Kevin R. MacKenzie
AU  - Josephine C. Ferreon
AU  - Allan Chris M. Ferreon
TI  - The N-terminal domain of ALS-linked TDP-43 assembles without misfolding
AID  - 10.1101/134072
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 134072
4099  - http://biorxiv.org/content/early/2017/05/04/134072.short
4100  - http://biorxiv.org/content/early/2017/05/04/134072.full
AB  - TDP-43 forms inclusions in several neurodegenerative diseases, and both its N- and C-terminal domains are implicated in this process. We show that the folded TDP-43 N-terminal domain oligomerizes under physiological conditions and propose that, in full-length TDP-43, association between folded N-terminal domains enhances the propensity of the intrinsically unfolded C-terminal domains to drive pathological aggregation.