TY - JOUR T1 - The Human Cell Atlas JF - bioRxiv DO - 10.1101/121202 SP - 121202 AU - Aviv Regev AU - Sarah A. Teichmann AU - Eric S. Lander AU - Ido Amit AU - Christophe Benoist AU - Ewan Birney AU - Bernd Bodenmiller AU - Peter Campbell AU - Piero Carninci AU - Menna Clatworthy AU - Hans Clevers AU - Bart Deplancke AU - Ian Dunham AU - James Eberwine AU - Roland Eils AU - Wolfgang Enard AU - Andrew Farmer AU - Lars Fugger AU - Berthold Göttgens AU - Nir Hacohen AU - Muzlifah Haniffa AU - Martin Hemberg AU - Seung Kim AU - Paul Klenerman AU - Arnold Kriegstein AU - Ed Lein AU - Sten Linnarsson AU - Joakim Lundeberg AU - Partha Majumder AU - John C. Marioni AU - Miriam Merad AU - Musa Mhlanga AU - Martijn Nawijn AU - Mihai Netea AU - Garry Nolan AU - Dana Pe’er AU - Anthony Phillipakis AU - Chris P. Ponting AU - Steve Quake AU - Wolf Reik AU - Orit Rozenblatt-Rosen AU - Joshua Sanes AU - Rahul Satija AU - Ton N. Schumacher AU - Alex Shalek AU - Ehud Shapiro AU - Padmanee Sharma AU - Jay W. Shin AU - Oliver Stegle AU - Michael Stratton AU - Michael J. T. Stubbington AU - Alexander van Oudenaarden AU - Allon Wagner AU - Fiona Watt AU - Jonathan Weissman AU - Barbara Wold AU - Ramnik Xavier AU - Nir Yosef AU - the Human Cell Atlas Meeting Participants Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/08/121202.abstract N2 - The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body, by undertaking a Human Cell Atlas Project as an international collaborative effort. The aim would be to define all human cell types in terms of distinctive molecular profiles (e.g., gene expression) and connect this information with classical cellular descriptions (e.g., location and morphology). A comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, as well as provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas. ER -