RT Journal Article
SR Electronic
T1 Visualization and label-free quantification of microfluidic mixing using quantitative phase imaging
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 137117
DO 10.1101/137117
A1 GwangSik Park
A1 Dongsik Han
A1 GwangSu Kim
A1 Seungwoo Shin
A1 Kyoohyun Kim
A1 Je-Kyun Park
A1 YongKeun Park
YR 2017
UL http://biorxiv.org/content/early/2017/05/12/137117.abstract
AB Microfluidic mixing plays a key role in various fields, including biomedicine and chemical engineering. To date, although various approaches for imaging microfluidic mixing have been proposed, they provide only quantitative imaging capability and require for exogenous labeling agents. Quantitative phase imaging techniques, however, circumvent these problems and offer label-free quantitative information about concentration maps of microfluidic mixing. We present the quantitative phase imaging of microfluidic mixing in various types of PDMS microfluidic channels with different geometries; the feasibility of the present method was validated by comparing it with the results obtained by theoretical calculation based on Fick’s law.