TY - JOUR T1 - Epistasis and Entropy JF - bioRxiv DO - 10.1101/014829 SP - 014829 AU - Kristina Crona Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/03/03/014829.abstract N2 - Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large system where systematic fitness measurements may not be possible. Some recent approaches depend on information theory. We show that considering shared entropy for pairs of loci can be misleading. The reason is that shared entropy does not imply epistasis for the pair. This observation holds true also in the absence of higher order epistasis. We discuss a refined approach for identifying pairwise interactions using entropy. ER -