TY - JOUR T1 - Population coding of conditional probability distributions in dorsal premotor cortex JF - bioRxiv DO - 10.1101/137026 SP - 137026 AU - Joshua I. Glaser AU - Matthew G. Perich AU - Pavan Ramkumar AU - Lee E. Miller AU - Konrad P. Kording Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/17/137026.abstract N2 - Our bodies and the environment constrain our movements. For example, when our arm is fully outstretched, we cannot extend it further. More generally, the distribution of possible movements is conditioned on the state of our bodies in the environment, which is constantly changing. However, little is known about how the brain represents such distributions, and uses them in movement planning. Here, we recorded from dorsal premotor cortex (PMd) and primary motor cortex (M1) while monkeys reached to randomly placed targets. The hand's position within the workspace created probability distributions of possible upcoming targets, which affected movement trajectories and latencies. PMd, but not M1, neurons had increased activity when the monkey's hand position made it likely the upcoming movement would be in the neurons’ preferred directions. Across the population, PMd activity represented probability distributions of individual upcoming reaches, which depended on rapidly changing information about the body's state in the environment. ER -