PT  - JOURNAL ARTICLE
AU  - Nicholas K. Akers
AU  - Eric E. Schadt
AU  - Bojan Losic
TI  - STAR Chimeric Post For Rapid Detection of Circular RNA and Fusion Transcripts
AID  - 10.1101/139808
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 139808
4099  - http://biorxiv.org/content/early/2017/05/18/139808.short
4100  - http://biorxiv.org/content/early/2017/05/18/139808.full
AB  - Motivation The biological relevance of chimeric RNA alignments is now well established. Chimera arising as chromosomal fusions are often drivers of cancer, and recently discovered circular RNA are only now being characterized. While software already exists for fusion discovery and quantitation, high false positive rates and high run-times hamper scalable fusion discovery on large datasets. Furthermore, very little software is available for circular RNA detection and quantification.Results Here we present STAR Chimeric Post (STARChip), a novel software package that processes chimeric alignments from the STAR aligner and produces annotated circular RNA and high precision fusions in a rapid, efficient, and scalable manner that is appropriate for high dimensional medical omics datasets.Availability and Implementation STARChip is available at https://github.com/LosicLab/STARChipContacts bojan.losic{at}mssm.edu or nicholas.kipp.akers{at}gmail.comSupplementary Information Supplementary figures and tables are available online.