RT Journal Article
SR Electronic
T1 Diet and life stage associated remodeling of lipid metabolism regulation in the duplicated Atlantic salmon genome
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 140442
DO 10.1101/140442
A1 Gareth Gillard
A1 Thomas N. Harvey
A1 Arne Gjuvsland
A1 Yang Jin
A1 Magny Thomassen
A1 Sigbjørn Lien
A1 Michael Leaver
A1 Jacob S. Torgersen
A1 Torgeir R. Hvidsten
A1 Jon Olav Vik
A1 Simen R. Sandve
YR 2017
UL http://biorxiv.org/content/early/2017/05/22/140442.abstract
AB Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. These habitat shifts require great phenotypic plasticity. To address the unresolved question of how the shift in diet between fresh and saltwater affects the regulation of metabolic function, we fed salmon contrasting diets in each of the two life stages. Combining transcriptomics with comparative genomics, we found that lipid metabolism undergoes a concerted shift between fresh- and saltwater stages. Lipogenesis and lipid transport become less active in liver after transition to saltwater, while genes involved in uptake of dietary lipids in gut greatly increases in lipid-rich seawater environments. We assess how the whole-genome duplication ancestral to salmonids has impacted the evolution of lipid metabolism, and find signatures of pathway-specific selection pressure on gene duplicates and a limited number of cases of increased gene dosage.