TY - JOUR T1 - The Structure of Small Beta Barrels JF - bioRxiv DO - 10.1101/140376 SP - 140376 AU - Philippe Youkharibache AU - Stella Veretnik AU - Qingliang Li AU - Philip E. Bourne Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/22/140376.abstract N2 - The small beta barrel is a protein structural domain, highly conserved throughout evolution and hence exhibits a broad diversity of functions. Here we undertake a comprehensive review of the structural features of this domain. We begin with what characterizes the structure and the variable nomenclature that has been used to describe it. We then go on to explore the anatomy of the structure and how functional diversity is achieved, including through establishing a variety of multimeric states, which, if misformed, contribute to disease states. We conclude with work following from such a comprehensive structural study. ER -