RT Journal Article
SR Electronic
T1 Revealing the Distribution of Transmembrane Currents along the Dendritic Tree of a Neuron with Known Morphology from Extracellular Recordings
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 141069
DO 10.1101/141069
A1 Dorottya Cserpán
A1 Domokos Meszéna
A1 Lucia Wittner
A1 Kinga Tóth
A1 István Ulbert
A1 Zoltán Somogyvári
A1 Daniel K. Wójcik
YR 2017
UL http://biorxiv.org/content/early/2017/05/23/141069.abstract
AB Revealing the membrane current source distribution of neurons is a key step on the way to understanding neural computations, however, the experimental and theoretical tools to achieve sufficient spatiotemporal resolution for the estimation remain to be established. Here we address this problem using extracellularly recorded potentials with arbitrarily distributed electrodes in a neuron of known morphology. We use simulations of models with varying complexity to validate the proposed method and to give recommendations for experimental applications. The method is applied to in vitro data from rat hippocampus.