TY - JOUR T1 - TiSAn: tissue specific variant annotation JF - bioRxiv DO - 10.1101/141408 SP - 141408 AU - Kévin Vervier AU - Jacob J Michaelson Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/24/141408.abstract N2 - The impact of genetic variation on molecular functions, such as gene expression, varies across tissues and cell types, complicating the interpretation of genetic variants. We introduce a functional Tissue-Specific Annotation (TiSAn) tool that predicts how related a genomic position is to a given tissue (http://github.com/kevinVervier/TiSAn). We demonstrate the accuracy and versatility of TiSAn by introducing predictive models for human heart and human brain, and detecting tissue-relevant variations in large cohorts for autism spectrum disorder and coronary artery disease. ER -