PT  - JOURNAL ARTICLE
AU  - B Ng
AU  - CC White
AU  - H Klein
AU  - S.K. Sieberts
AU  - C McCabe
AU  - E Patrick
AU  - J Xu
AU  - L Yu
AU  - C Gaiteri
AU  - DA Bennett
AU  - S Mostafavi
AU  - L De Jager
TI  - Brain xQTL map: integrating the genetic architecture of the human brain transcriptome and epigenome
AID  - 10.1101/142927
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 142927
4099  - http://biorxiv.org/content/early/2017/05/27/142927.short
4100  - http://biorxiv.org/content/early/2017/05/27/142927.full
AB  - We perform quantitative trait locus (xQTL) analyses on a multi-omic dataset, comprising RNA sequence, DNA methylation, and histone acetylation ChIP sequence data from the dorsolateral prefrontal cortex of 411 older adult individuals. We identify SNPs that are significantly associated with gene expression, DNA methylation, and histone modification levels. Many SNPs influence more than one type of molecular feature, and epigenetic features are shown to mediate eQTLs in a number of (9%) such loci, but most shared xQTL SNPs display independent effects. We illustrate the utility of our new resource, xQTL Serve, in prioritizing the cell type most affected by an xQTL and in enhancing genome wide association studies (GWAS) as we report 18 additional CNS disease susceptibility loci after re-analyzing published studies.