TY - JOUR T1 - Sensitivity analysis of Wnt <em>β</em>-catenin based transcription complex might bolster logarithmic psychophysical law and reveal preserved gene gene interactions JF - bioRxiv DO - 10.1101/015834 SP - 015834 AU - Shriprakash Sinha Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/03/18/015834.abstract N2 - Sensitivity analysis plays a crucial role in observing the behaviour of output of a variable given variations in the input. In colorectal cancer, β-catenin based transcription complex (TRCMPLX) plays a major role in driving the Wnt signaling pathway. In this manuscript, the variation in the effect of the predictive behaviour of TRCMPLX conditional on the evidences of regulated gene expressions in normal and tumor samples is observed by varying the initially assigned values of conditional probability tables (cpt) for TRCMPLX. Preliminary analysis shows that the variation in predictive behaviour of TRCMPLX conditional on gene evidences follows logarithmic psychophysical law crudely, implying deviations in output are proportional to increasing function of deviations in input and showing constancy for higher values of input. This points towards stability in the behaviour of TRCMPLX and is reflected in the preserved gene gene interactions of the Wnt pathway inferred from conditional probabilities of individual gene activation given the status of another gene activation derived using biologically inspired Bayesian Network. ER -