PT  - JOURNAL ARTICLE
AU  - Clemens L. Weiß
AU  - Marina Pais
AU  - Liliana M. Cano
AU  - Sophien Kamoun
AU  - Hernán A. Burbano
TI  - nQuire: A statistical framework for ploidy estimation using next generation sequencing
AID  - 10.1101/143537
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 143537
4099  - http://biorxiv.org/content/early/2017/05/29/143537.short
4100  - http://biorxiv.org/content/early/2017/05/29/143537.full
AB  - Summary nQuire is a statistical framework that distinguishes between diploids, triploids and tetraploids using next generation sequencing. The command-line tool models the distribution of base frequencies at variable sites using a Gaussian Mixture Model, and uses maximum likelihood to select the most plausible ploidy model.Availability and Implementation The model is implemented as a stand-alone Linux command line tool in the C programming language and is available at github under the MIT licence. Please also refer to github.com/clwgg/nQuire for usage instructions. Contact: clemens.weiss{at}tuebingen.mpg.de or hernan.burbano{at}tuebingen.mpg.de