TY - JOUR T1 - nQuire: A statistical framework for ploidy estimation using next generation sequencing JF - bioRxiv DO - 10.1101/143537 SP - 143537 AU - Clemens L. Weiß AU - Marina Pais AU - Liliana M. Cano AU - Sophien Kamoun AU - Hernán A. Burbano Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/29/143537.abstract N2 - Summary nQuire is a statistical framework that distinguishes between diploids, triploids and tetraploids using next generation sequencing. The command-line tool models the distribution of base frequencies at variable sites using a Gaussian Mixture Model, and uses maximum likelihood to select the most plausible ploidy model.Availability and Implementation The model is implemented as a stand-alone Linux command line tool in the C programming language and is available at github under the MIT licence. Please also refer to github.com/clwgg/nQuire for usage instructions. Contact: clemens.weiss{at}tuebingen.mpg.de or hernan.burbano{at}tuebingen.mpg.de ER -