RT Journal Article SR Electronic T1 Advancing a Science for Sustaining Health: Establishing a Model Health District in Madagascar JF bioRxiv FD Cold Spring Harbor Laboratory SP 141549 DO 10.1101/141549 A1 Matthew H. Bonds A1 Andres Garchitorena A1 Laura Cordier A1 Ann C. Miller A1 Margaret McCarty A1 Benjamin Andriamihaja A1 Josea Ratsirarson A1 Andriamihaja Randrianambinina A1 Victor R. Rabeza A1 Karen Finnegan A1 Thomas Gillespie A1 Patricia A. Wright A1 Paul E. Farmer A1 Tara Loyd A1 Megan B. Murray A1 Robin M. Herrnstein A1 James R. Herrnstein A1 PIVOT Impact Team A1 Djordje Gikic A1 Mohammed A. Ouenzar A1 Lara Hall A1 Michael L. Rich YR 2017 UL http://biorxiv.org/content/early/2017/05/30/141549.abstract AB Objective We demonstrate a replicable model health district for Madagascar. The governments of many low-income countries have adopted health policies that follow international standards, and yet there are four hundred million people without basic access to primary care. Closing this global health delivery gap is typically framed as an issue of scale-up, accomplished primarily through integrating international donor funds with broad-based health system strengthening (HSS) efforts. However, there is no established process by which healthcare systems measure improvements at the point of service and how those, in turn, impact population health. There is no gold standard, equivalent to randomized trials of individual-level interventions, for health systems research. Here, we present a framework for a model district in Madagascar where national policies are implemented along with additional health system interventions to allow for bottom-up adaptation.Setting The intervention takes place in a government district in Madagascar, which includes 1 district hospital, 20 primary care health centers, and a network of community health workers.Intervention The program simultaneously strengthens the WHO’s six building blocks of HSS at all levels of the health system within a government district and pioneers a data platform that includes 1) strengthening the district’s health management information systems; 2) monitoring and evaluation dashboards; and 3) a longitudinal cohort demographic and health study of over 1,500 households, with a true baseline in intervention and comparison groups.Conclusion The integrated intervention and data platform allows for the evaluation of system output indicators as well as population-level impact indicators, such as mortality rates. It thus supports field-based implementation and policy research to fill the know-do gap, while providing the foundation for a new science of sustaining health.Data Sharing Statement Data can be made available upon request by emailing research{at}pivotworks.org.