RT Journal Article
SR Electronic
T1 Impairment of zebrafish reproduction upon exposure to melengestrol acetate
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 146506
DO 10.1101/146506
A1 Kewen Xiong
A1 Chunyun Zhong
A1 Xin Wang
YR 2017
UL http://biorxiv.org/content/early/2017/06/06/146506.abstract
AB Synthetic progestins contamination is common in the aquatic ecosystem, which may lead to serious health problem on aquatic animals. Melengestrol acetate (MGA) has been detected in the aquatic environment; however, its potential effects on fish reproduction are largely unclear. Here, we aimed to investigate the endocrine disruption and impact of MGA on zebrafish reproduction. Six-month old reproductive zebrafish were exposed to four nominal concentrations of MGA (1,10, 100 and 200 ng/L) for 15 days. Treatment with MGA reduced the egg production with a significant decrease at 200 ng/L. The circulating concentrations of estradiol and testosterone in female zebrafish or 11-keto testosterone in male zebrafish were significantly diminished compared to the non-exposed control fish. The early embryonic development or hatching rates were unaffected during the MGA exposure. Our results indicated that MGA was a potent endocrine disruptor in fish and the fish reproduction could be impaired even during a short-term exposure to MGA.