PT  - JOURNAL ARTICLE
AU  - Carsten Bøcker Pedersen
AU  - Jonas Bybjerg-Grauholm
AU  - Marianne Giørtz Pedersen
AU  - Jakob Grove
AU  - Esben Agerbo
AU  - Marie Bækvad-Hansen
AU  - Jesper Buchhave Poulsen
AU  - Christine Sæholm Hansel
AU  - John J. McGrath
AU  - Thomas Damm Als
AU  - Jacqueline I. Goldstein
AU  - Ben M Neale
AU  - Mark J Daly
AU  - David M. Hougaard
AU  - Ole Mors
AU  - Merete Nordentoft
AU  - Anders D. Børglum
AU  - Thomas Werge
AU  - Preben Bo Mortensen
TI  - The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders
AID  - 10.1101/146670
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 146670
4099  - http://biorxiv.org/content/early/2017/06/06/146670.short
4100  - http://biorxiv.org/content/early/2017/06/06/146670.full
AB  - The iPSYCH consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born 1981-2005 including 1,472,762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3,540), autism (N=16,146), ADHD (N=18,726), and affective disorder (N=26,380), of which 1928 had bipolar affective disorder. Controls were randomly sampled individuals (N=30,000). Within the sample of 86,189 individuals, a total of 57,377 individuals had at least one major mental disorder. DNA was extracted from the neonatal dried blood spot samples obtained from the Danish Neonatal Screening Biobank and genotyped using the Illumina PsychChip. Genotyping was successful for 90% of the sample. The assessments of exome sequencing, methylation profiling, metabolome profiling, vitamin-D, inflammatory and neurotrophic factors are in progress. For each individual, the iPSYCH2012 sample also includes longitudinal information on health, prescribed medicine, social and socioeconomic information and analogous information among relatives. To the best of our knowledge, the iPSYCH2012 sample is the largest and most comprehensive data source for the combined study of genetic and environmental aetiologies of severe mental disorders.