TY - JOUR T1 - Interhemispheric specialization in the rodent hippocampus: Implications for storage and retrieval of short- and long-term memories JF - bioRxiv DO - 10.1101/150193 SP - 150193 AU - Jake Jordan AU - Carolyn Pytte Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/06/14/150193.abstract N2 - Lateralization is an organizing principle of nervous systems across taxa. The human hippocampus is known to be lateralized with respect to memory and spatial navigation. In contrast, the rodent hippocampus has been traditionally thought of as a bilaterally symmetric structure, as early studies did not uncover functional differences between the left and right hemispheres. Moreover, it is a common view that the primate hippocampus lacks strong, interhemispheric projections between the bilateral hippocampi, which are present in the rodent brain. Advances in experimental technology have resulted in discoveries of hemispheric asymmetries in the rodent hippocampus, which have led to more sophisticated hypotheses of bilateral hippocampal function. Here, we review studies on hippocampal lateralization with a particular focus on the rodent brain, and suggest that there are more similarities between the human and rodent hippocampus than previously thought. We propose novel hypotheses to uncover the contributions of the left and right hemisphere to hippocampal processing and cognition. ER -