RT Journal Article
SR Electronic
T1 An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 150730
DO 10.1101/150730
A1 F.G. Malinovsky
A1 M-L.F. Thomsen
A1 S.J. Nintemann
A1 L.M. Jagd
A1 B. Bourgine
A1 M. Burow
A1 D. J. Kliebenstein
YR 2017
UL http://biorxiv.org/content/early/2017/06/15/150730.abstract
AB To optimize fitness a plant should monitor its metabolism to appropriately control growth and defense. Primary metabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway to balance growth and development with the available energy and nutrients. Recent work suggests that plants may measure defense metabolites to potentially provide a strategy ensuring fast reallocation of resources to coordinate plant growth and defense. There is little understanding of mechanisms enabling defense metabolite signaling. To identify mechanisms of defense metabolite signaling, we used glucosinolates, an important class of plant defense metabolites. We report novel signaling properties specific to one distinct glucosinolate, 3- hydroxypropyl glucosinolate across plants and fungi. This defense metabolite, or derived compounds, reversibly inhibits root growth and development. 3-hydroxypropyl glucosinolate signaling functions via genes in the ancient TOR pathway. Thus, plants might link evolutionarily new defense metabolites to ancient signaling pathways to optimize energy allocation.