PT - JOURNAL ARTICLE AU - David Tamborero AU - Carlota Rubio-Perez AU - Jordi Deu-Pons AU - Michael P Schroeder AU - Ana Vivancos AU - Ana Rovira AU - Ignasi Tusquets AU - Joan Albanell AU - Jordi Rodon AU - Josep Tabernero AU - Carmen de Torres AU - Rodrigo Dienstmann AU - Abel Gonzalez-Perez AU - Nuria Lopez-Bigas TI - Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations AID - 10.1101/140475 DP - 2017 Jan 01 TA - bioRxiv PG - 140475 4099 - http://biorxiv.org/content/early/2017/06/21/140475.short 4100 - http://biorxiv.org/content/early/2017/06/21/140475.full AB - While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Most of the alterations observed in tumors, including those in well-known cancer genes, are of uncertain significance. Moreover, the information on tumor genomic alterations shaping the response to existing therapies is fragmented across the literature and several specialized resources. Here we present the Cancer Genome Interpreter (http://www.cancergenomeinterpreter.org), an open access tool that we have implemented to annotate genomic alterations and interpret their possible role in tumorigenesis and in the response to anti-cancer therapies.