PT  - JOURNAL ARTICLE
AU  - Mauro M Monsalve-Mercado
AU  - Christian Leibold
TI  - Hippocampal Spike-Timing Correlations Lead to Hexagonal Grid Fields
AID  - 10.1101/153379
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 153379
4099  - http://biorxiv.org/content/early/2017/06/21/153379.short
4100  - http://biorxiv.org/content/early/2017/06/21/153379.full
AB  - Space is represented in the mammalian brain by the activity of hippocampal place cells as well as in their spike-timing correlations. Here we propose a theory how this temporal code is transformed to spatial firing rate patterns via spike-timing-dependent synaptic plasticity. The resulting dynamics of synaptic weights resembles well-known pattern formation models in which a lateral inhibition mechanism gives rise to a Turing instability. We identify parameter regimes in which hexagonal firing patterns develop as they have been found in medial entorhinal cortex.