RT Journal Article
SR Electronic
T1 Coupling of replisome movement with nucleosome dynamics can contribute to the parent-daughter information transfer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 154559
DO 10.1101/154559
A1 Tripti Bameta
A1 Dibyendu Das
A1 Ranjith Padinhateeri
YR 2017
UL http://biorxiv.org/content/early/2017/06/23/154559.abstract
AB Positioning of nucleosomes along the genomic DNA is crucial for many cellular processes that include gene regulation and higher order packaging of chromatin. The question of how nucleosome-positioning information from a parent chromatin gets transferred to the daughter chromatin is highly intriguing. Accounting for experimentally known coupling between replisome movement and nucleosome dynamics, we propose a model that can explain the inheritance of nucleosome positioning. Simulating nucleosome dynamics during replication we argue that short pausing of the replication fork, associated with nucleosome disassembly, can be the event crucial for communicating nucleosome positioning information from parent to daughter. We show that the interplay of timescales between nucleosome disassembly (τp) at the replication fork and nucleosome sliding behind the fork (τs) can give rise to a rich “phase diagram” having different inherited patterns of nucleosome organization. Our model predicts that only when τp ≥ τs the daughter chromatin can inherit the precise nucleosome positioning of the parent.