TY - JOUR T1 - Data Resource Profile: Generation Scotland Electronic Health Record JF - bioRxiv DO - 10.1101/154609 SP - 154609 AU - Shona M. Kerr AU - Archie Campbell AU - Jonathan Marten AU - Veronique Vitart AU - Andrew McIntosh AU - David J. Porteous AU - Caroline Hayward Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/06/23/154609.abstract N2 - The Generation Scotland Electronic Health Record data resource is a key component of the Generation Scotland Scottish Family Health Study (GS:SFHS)1, a biobank conceived in 1999 (www.generationscotland.org) for the purpose of studying the genetics of health areas of current and projected public health importance.2 GS:SFHS is a large, family-based, intensively-phenotyped cohort of volunteers from the general population across Scotland, UK. The median age at recruitment was 47 for males and 48 for females, and the cohort has 99% white ethnicity.1 Over 24 000 adults were recruited from 2006 to 2011, with broad and enduring written informed consent for biomedical research. Specific consent was obtained from 23 603 participants for GS:SFHS study data to be linked to their Scottish National Health Service (NHS) records, using their Community Health Index (CHI) number. This identifying number is used for NHS Scotland procedures (registrations, attendances, samples, prescribing and investigations) and allows healthcare records for individuals to be linked across time and location.3 Here, we describe the NHS electronic health record (EHR) dataset on the sub-cohort of 20 032 GS:SFHS participants with consent and mechanism for record linkage plus extensive genetic (both directly measured and imputed genotype) data. Together with existing study phenotypes, including family history and environmental exposures such as smoking, the EHR is a rich resource of real world data that can be used in research to characterise the health trajectory of participants, available at low cost and a high degree of timeliness, matched to DNA, urine and serum samples and detailed genetic information. ER -