RT Journal Article SR Electronic T1 Genome-wide analysis reveals novel regulators of growth in Drosophila melanogaster JF bioRxiv FD Cold Spring Harbor Laboratory SP 017855 DO 10.1101/017855 A1 Sibylle Chantal Vonesch A1 David Lamparter A1 Trudy FC Mackay A1 Sven Bergmann A1 Ernst Hafen YR 2015 UL http://biorxiv.org/content/early/2015/04/10/017855.abstract AB Organismal size depends on the interplay between genetic and environmental factors. Genome-wide association (GWA) analyses in humans have implied many genes in the control of height but suffer from the inability of controlling the environment. Genetic analyses in Drosophila have identified conserved signaling pathways controlling size; however, how these pathways control phenotypic diversity is unclear. We performed GWA of size traits using the Drosophila Genetic Reference Panel of inbred, sequenced lines and find that top variants are predominantly sex-specific; do not map to canonical growth pathway genes, but can be linked to these by epistasis analysis; and are enriched in homologs of genes involved in human height regulation. Performing GWA on well-studied developmental traits under controlled conditions expands our understanding of developmental processes underlying phenotypic diversity.