RT Journal Article
SR Electronic
T1 In vivo magnetic recording of neuronal activity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 092569
DO 10.1101/092569
A1 Laure Caruso
A1 Thomas Wunderle
A1 Christopher Murphy Lewis
A1 Joao Valadeiro
A1 Vincent Trauchessec
A1 Josué Trejo Rosillo
A1 José Pedro Amaral
A1 Jianguang Ni
A1 Patrick Jendritza
A1 Claude Fermon
A1 Susana Cardoso
A1 Paulo Peixeiro Freitas
A1 Pascal Fries
A1 Myriam Pannetier-Lecoeur
YR 2017
UL http://biorxiv.org/content/early/2017/06/26/092569.abstract
AB Neuronal activity generates ionic flows and thereby both magnetic fields and electric potential differences, i.e. voltages. Voltage measurements are widely used, but suffer from isolating and smearing properties of tissue between source and sensor, are blind to ionic flow direction, and reflect the difference between two electrodes, complicating interpretation. Magnetic field measurements could overcome these limitations, but have been essentially limited to magnetoencephalography (MEG), using centimeter-sized, helium-cooled extracranial sensors. Here, we report on in vivo magnetic recordings of neuronal activity from visual cortex of cats with magnetrodes, specially developed needle-shaped probes carrying micron-sized, non-cooled magnetic sensors based on spin electronics. Event-related magnetic fields inside the neuropil were on the order of several nanoteslas, informing MEG source models and efforts for magnetic field measurements through MRI. Though the signal-to-noise ratio is still inferior to electrophysiology, this proof of concept demonstrates the potential to exploit the fundamental advantages of magnetophysiology.HIGHLIGHTSSpin-electronics based probes achieve local magnetic recordings inside the neuropilMagnetic field recordings were performed in vivo, in anesthetized cat visual cortexEvent-related fields (ERFs) to visual stimuli were up to several nanoteslas in sizeERFs could be detected after averaging less than 20 trialsIN BRIEF Caruso et al. report in vivo, intra-cortical recordings of magnetic fields that reflect neuronal activity, using magnetrodes, i.e. micron size magnetic sensors based on spin electronics.