TY - JOUR T1 - Feedforward inhibition allows input summation to vary in recurrent cortical networks JF - bioRxiv DO - 10.1101/109736 SP - 109736 AU - Mark H. Histed Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/06/28/109736.abstract N2 - Brain computations depend on how neurons transform inputs to spike outputs. Here, to understand input-output transformations in cortical networks, we recorded spiking responses from visual cortex (V1) of awake mice of either sex while pairing sensory stimuli with optogenetic perturbation of excitatory and parvalbumin-positive inhibitory neurons. We found V1 neurons’ average responses were primarily additive (linear). We used a recurrent cortical network model to determine if these data, as well as past observations of nonlinearity, could be described by a common circuit architecture. The model showed cortical input-output transformations can be changed from linear to sublinear with moderate (∼20%) strengthening of connections between inhibitory neurons, but this change depends on the presence of feedforward inhibition. Thus, feedforward inhibition, a common feature of cortical circuitry, enables networks to flexibly change their spiking responses via changes in recurrent connectivity.Significance statement Brains are made up of neural networks that process information by receiving input activity and transforming those inputs into output activity. We use optogenetic manipulations in awake mice to expose how a transformation in a cortical network depends on internal network activity. Combining numerical simulations with our observations uncovers that transformation depend critically on feedforward inhibition – the fact that inputs to the cortex often make strong connections on both excitatory and inhibitory neurons. ER -