TY - JOUR T1 - Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate JF - bioRxiv DO - 10.1101/092874 SP - 092874 AU - Anna J. Jasinska AU - Ivette Zelaya AU - Susan K. Service AU - Christine B. Peterson AU - Rita M. Cantor AU - Oi-Wa Choi AU - Joseph DeYoung AU - Eleazar Eskin AU - Lynn A. Fairbanks AU - Scott Fears AU - Allison E. Furterer AU - Yu S. Huang AU - Vasily Ramensky AU - Christopher A. Schmitt AU - Hannes Svardal AU - Matthew J. Jorgensen AU - Jay R. Kaplan AU - Diego Villar AU - Bronwen L. Aken AU - Paul Flicek AU - Rishi Nag AU - Emily S. Wong AU - John Blangero AU - Thomas D. Dyer AU - Marina Bogomolov AU - Yoav Benjamini AU - George M. Weinstock AU - Ken Dewar AU - Chiara Sabatti AU - Richard K. Wilson AU - J. David Jentsch AU - Wesley Warren AU - Giovanni Coppola AU - Roger P. Woods AU - Nelson B. Freimer Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/07/06/092874.abstract N2 - By analyzing multi-tissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalogue of expression quantitative trait loci (eQTLs) in a non-human primate model. This catalogue contains more genome-wide significant eQTLs, per sample, than comparable human resources, and reveals sex and age-related expression patterns. Findings include a master regulatory locus that likely plays a role in immune function, and a locus regulating hippocampal long non-coding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders. ER -