RT Journal Article
SR Electronic
T1 Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 092874
DO 10.1101/092874
A1 Anna J. Jasinska
A1 Ivette Zelaya
A1 Susan K. Service
A1 Christine B. Peterson
A1 Rita M. Cantor
A1 Oi-Wa Choi
A1 Joseph DeYoung
A1 Eleazar Eskin
A1 Lynn A. Fairbanks
A1 Scott Fears
A1 Allison E. Furterer
A1 Yu S. Huang
A1 Vasily Ramensky
A1 Christopher A. Schmitt
A1 Hannes Svardal
A1 Matthew J. Jorgensen
A1 Jay R. Kaplan
A1 Diego Villar
A1 Bronwen L. Aken
A1 Paul Flicek
A1 Rishi Nag
A1 Emily S. Wong
A1 John Blangero
A1 Thomas D. Dyer
A1 Marina Bogomolov
A1 Yoav Benjamini
A1 George M. Weinstock
A1 Ken Dewar
A1 Chiara Sabatti
A1 Richard K. Wilson
A1 J. David Jentsch
A1 Wesley Warren
A1 Giovanni Coppola
A1 Roger P. Woods
A1 Nelson B. Freimer
YR 2017
UL http://biorxiv.org/content/early/2017/07/06/092874.abstract
AB By analyzing multi-tissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalogue of expression quantitative trait loci (eQTLs) in a non-human primate model. This catalogue contains more genome-wide significant eQTLs, per sample, than comparable human resources, and reveals sex and age-related expression patterns. Findings include a master regulatory locus that likely plays a role in immune function, and a locus regulating hippocampal long non-coding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.