TY - JOUR T1 - A common neural network among state, trait, and pathological anxiety from whole-brain functional connectivity JF - bioRxiv DO - 10.1101/158055 SP - 158055 AU - Yu Takagi AU - Yuki Sakai AU - Yoshinari Abe AU - Seiji Nishida AU - Ben J. Harrison AU - Ignacio Martínez-Zalacaín AU - Carles Soriano-Mas AU - Jin Narumoto AU - Saori C. Tanaka Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/07/07/158055.abstract N2 - Anxiety is one of the most common mental states of humans. Although it drives us to avoid frightening situations and to achieve our goals, it may also impose significant suffering and burden if it becomes extreme. Because we experience anxiety in a variety of forms, previous studies investigated neural substrates of anxiety in a variety of ways. These studies revealed that individuals with high state, trait, or pathological anxiety showed altered neural substrates. However, no studies have directly investigated whether the different dimensions of anxiety share a common neural substrate, despite its theoretical and practical importance. Here, we investigated a neural network of anxiety shared by different dimensions of anxiety in a unified analytical framework using functional magnetic resonance imaging (fMRI). We analyzed different datasets in a single scale, which was defined by an anxiety-related neural network derived from whole brain. Through the fMRI task for provoking anxiety, we found a common neural network of state anxiety across participants (1,638 trials obtained from 10 participants). Then, using the resting-state fMRI in combination with the participants’ trait anxiety scale (879 participants from the Human Connectome Project), we demonstrated that trait anxiety also shared the same neural network as state anxiety. Furthermore, the common neural network between state and trait anxiety could detect patients with obsessive-compulsive disorder, which is characterized by pathological anxiety-driven behaviors (174 participants from multi-site datasets). Our findings provide direct evidence that different dimensions of anxiety are not completely independent but have a substantial biological inter-relationship. Our results also provide a biologically defined dimension of anxiety, which may promote further investigation of various human characteristics, including psychiatric disorders, from the perspective of anxiety. ER -