@article {Asokan162909, author = {Meenakshi M Asokan and Ross S Williamson and Kenneth E Hancock and Daniel B Polley}, title = {Homeostatic normalization of sensory gain in auditory corticofugal feedback neurons}, elocation-id = {162909}, year = {2017}, doi = {10.1101/162909}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Sensory corticofugal neurons regulate gain and guide adaptive plasticity supporting innate and learned behaviors through their massive, widespread projections to subcortical sensory and motor nuclei. Little is known about the intrinsic, naturally occurring plasticity within corticofugal feedback neurons themselves, due to technical challenges associated with targeted long-term recordings from distributed deep layer cortical neurons. Here, we describe a chronic widefield Ca2+ axon imaging approach to track day-by-day dynamics in auditory corticocollicular (CCol) sound processing following auditory deprivation in adult mice. CCol responses were suppressed immediately following noise damage but rapidly returned to baseline levels despite ongoing elevation of cochlear thresholds. CCol response gain was potentiated for several days before stabilizing at baseline levels within six days after noise damage. These findings demonstrate a homeostatic plasticity in auditory corticofugal neurons that compensates both for a temporary elevation of cochlear thresholds and a permanent loss of cochlear afferent synapses.}, URL = {https://www.biorxiv.org/content/early/2017/07/13/162909}, eprint = {https://www.biorxiv.org/content/early/2017/07/13/162909.full.pdf}, journal = {bioRxiv} }