RT Journal Article
SR Electronic
T1 Subgenual anterior cingulate cortex controls sadness-induced modulations of cognitive and emotional network hubs
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 163709
DO 10.1101/163709
A1 Juan P. Ramírez-Mahaluf
A1 Joan Perramon
A1 Begonya Otal
A1 Pablo Villoslada
A1 Albert Compte
YR 2017
UL http://biorxiv.org/content/early/2017/07/14/163709.abstract
AB The regulation of cognitive and emotional processes is critical for proper executive functions and social behavior, but its specific mechanisms remain unknown. Here, we addressed this issue by studying with functional magnetic resonance imaging the changes in network topology that underlie competitive interactions between emotional and cognitive networks in healthy participants. Our behavioral paradigm contrasted periods with high emotional and cognitive demands by including a sadness provocation task followed by a spatial working memory task. We hypothesized that this paradigm would enhance the modularity of emotional and cognitive networks and reveal the hub areas that regulate the flow of information between them. By applying graph analysis methods on functional connectivity between 20 regions of interest in 22 participants we identified two main brain network modules, one cognitive and one emotional, and their hub areas: the left dorsolateral prefrontal cortex (dlPFC) and the left medial frontal pole (mFP). These hub areas did not modulate their mutual functional connectivity following sadness but they did so through an interposed area, the subgenual anterior cingulate cortex (sACC). Our results identify dlPFC and mFP as areas regulating interactions between emotional and cognitive networks, and suggest that their modulation by sadness experience is mediated by sACC.