RT Journal Article
SR Electronic
T1 A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 018929
DO 10.1101/018929
A1 Hang Zhou
A1 Sile Hu
A1 Rostislav Matveev
A1 Qianhui Yu
A1 Jing Li
A1 Philipp Khaitovich
A1 Li Jin
A1 Michael Lachmann
A1 Mark Stoneking
A1 Qiaomei Fu
A1 Kun Tang
YR 2015
UL http://biorxiv.org/content/early/2015/05/05/018929.abstract
AB The spatiotemporal distribution of recent human adaptation is a long standing question. We developed a new coalescent-based method that collectively assigned human genome regions to modes of neutrality or to positive, negative, or balancing selection. Most importantly, the selection times were estimated for all positive selection signals, which ranged over the last half million years, penetrating the emergence of anatomically modern human (AMH). These selection time estimates were further supported by analyses of the genome sequences from three ancient AMHs and the Neanderthals. A series of brain function-related genes were found to carry signals of ancient selective sweeps, which may have defined the evolution of cognitive abilities either before Neanderthal divergence or during the emergence of AMH. Particularly, signals of brain evolution in AMH are strongly related to Alzheimer’s disease pathways. In conclusion, this study reports a chronological atlas of natural selection in Human.