RT Journal Article SR Electronic T1 GDSCTools for Mining Pharmacogenomic Interactions in Cancer JF bioRxiv FD Cold Spring Harbor Laboratory SP 166223 DO 10.1101/166223 A1 Thomas Cokelaer A1 Elisabeth Chen A1 Francesco Iorio A1 Michael P. Menden A1 Howard Lightfoot A1 Julio Saez-Rodriguez A1 Mathew J. Garnett YR 2017 UL http://biorxiv.org/content/early/2017/07/20/166223.abstract AB Motivation Large pharmacogenomic screenings integrate heterogeneous cancer genomic data sets as well as anti-cancer drug responses on thousand human cancer cell lines. Mining this data to identify new therapies for cancer sub-populations would benefit from common data structures, modular computational biology tools and user-friendly interfaces.Results We have developed GDSCTools: a software aimed at the identification of clinically relevant genomic markers of drug response. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) integrates heterogeneous cancer genomic data sets as well as anti-cancer drug responses on a thousand cancer cell lines. Including statistical tools (ANOVA) and predictive methods (Elastic Net), as well as common data structures, GDSCTools allows users to reproduce published results from GDSC, to analyse their own drug responses or genomic datasets, and to implement new analytical methods.Contact thomas.cokelaer{at}pasteur.fr