TY - JOUR T1 - Intrinsic brain connectivity after partial sleep deprivation in young and older adults: results from the Stockholm Sleepy Brain study JF - bioRxiv DO - 10.1101/073494 SP - 073494 AU - Gustav Nilsonne AU - Sandra Tamm AU - Johanna Schwarz AU - Rita Almeida AU - Håkan Fischer AU - Göran Kecklund AU - Mats Lekander AU - Peter Fransson AU - Torbjörn Åkerstedt Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/07/25/073494.abstract N2 - Sleep deprivation has been reported to affect intrinsic brain connectivity, notably reducing connectivity in the default mode network. Studies to date have however shown inconsistent effects, in many cases lacked monitoring of wakefulness, and largely included young participants. We investigated effects of sleep deprivation on intrinsic brain connectivity in young and older participants. Participants aged 20–30 (n=30) and 65–75 (n=23) years underwent partial sleep deprivation (3h sleep) in a cross-over design, with two 8-minutes eyes-open resting state functional magnetic resonance imaging (fMRI) runs in each session, monitored by eye-tracking. We assessed intrinsic brain connectivity using independent components analysis (ICA) as well as seed-region analyses of functional connectivity, and also analysed global signal variability, regional homogeneity, and the amplitude of low-frequency fluctuations. Sleep deprivation caused increased global signal variability. In our study, changes in investigated resting state networks and in regional homogeneity were not statistically significant. Younger participants had higher connectivity in most examined networks, as well as higher regional homogeneity in areas including anterior and posterior cingulate cortex. In conclusion, we found that sleep deprivation caused increased global signal variability. We speculate that this may be caused by wake-state instability. ER -