RT Journal Article
SR Electronic
T1 Objective, Quantitative, Data-Driven Assessment of Chemical Probes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 168369
DO 10.1101/168369
A1 Albert A. Antolin
A1 Joe E. Tym
A1 Angeliki Komianou
A1 Ian Collins
A1 Paul Workman
A1 Bissan Al-Lazikani
YR 2017
UL http://biorxiv.org/content/early/2017/07/25/168369.abstract
AB Chemical probes are essential tools for understanding biological systems and for target validation, yet selecting tools for biomedical research is largely biased and subjective. Here we describe the Probe Miner: Chemical Probes Objective Assessment resource – capitalising on the plethora of public medicinal chemistry data to empower quantitative, objective, Big Data-driven assessment of chemical probes. We assess >1.8m compounds for their suitability as chemical tools against 2,220 human targets and dissect their biases and limitations.