PT  - JOURNAL ARTICLE
AU  - Audrey Moine
AU  - Leon Espinosa
AU  - Eugenie Martineau
AU  - Deborah Byrne
AU  - Emanuele G. Biondi
AU  - Eugenio Notomista
AU  - Matteo Brilli
AU  - Virginie Molle
AU  - Tâm Mignot
AU  - Emilia M.F. Mauriello
TI  - The nucleoid as a scaffold for the assembly of bacterial signaling complexes
AID  - 10.1101/169912
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 169912
4099  - http://biorxiv.org/content/early/2017/07/28/169912.short
4100  - http://biorxiv.org/content/early/2017/07/28/169912.full
AB  - The FrzCD chemoreceptor from the gliding bacterium Myxococcus xanthus forms cytoplasmic clusters that occupy a large central region of the cell body also occupied by the nucleoid. In this work, we show that FrzCD directly binds to the nucleoid with its N-terminal positively charged tail and recruits active signaling complexes at this location. The FrzCD binding to the DNA leads to the formation of multiple distributed clusters that explore constrained areas. This supra-molecular organization is required for cooperative interactions between clustered receptors, in turn important for the modulation of bacterial social behaviors.