PT  - JOURNAL ARTICLE
AU  - Teppei Matsui
AU  - Tomonari Murakami
AU  - Kenichi Ohki
TI  - Neuronal orig in of the temporal dynamics of spontaneous BOLD activity correlation
AID  - 10.1101/169698
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 169698
4099  - http://biorxiv.org/content/early/2017/07/28/169698.short
4100  - http://biorxiv.org/content/early/2017/07/28/169698.full
AB  - Resting-state functional connectivity (FC) has become a major fMRI method to study network organization of human brains. There is recent interest in the temporal fluctuations of FC calculated using short time-windows (“dynamic FC”) because it could provide information inaccessible with conventional “static” FC that is typically calculated using the entire scan lasting several tens of minutes. Although multiple studies have revealed considerable temporal fluctuations in FC, it is still unclear whether the fluctuations of FC measured in hemodynamics reflect the dynamics of underlying neural activity. We addressed this question using simultaneous imaging of neuronal calcium and hemodynamic signals in mice, and found coordinated temporal dynamics of calcium FC and hemodynamic FC measured in the same short time windows. Moreover, we found that variation in transient neuronal coactivation patterns (CAPs) was significantly related to temporal fluctuations of sliding window FC in hemodynamics. Finally, we show that observed dynamics of FC cannot be fully accounted for by simulated data assuming stationary FC. These results provide evidence for the neuronal origin of dynamic FC and further suggest that information relevant to FC is condensed in temporally sparse events that can be extracted using a small number of time points.