TY - JOUR T1 - Oasis2.0: improved online analysis of small RNA-seq data JF - bioRxiv DO - 10.1101/170738 SP - 170738 AU - Raza-Ur Rahman AU - Abhivyakti Gautam AU - Jörn Bethune AU - Abdul Sattar AU - Maksims Fiosins AU - Daniel Sumner Magruder AU - Vincenzo Capece AU - Orr Shomroni AU - Stefan Bonn Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/08/01/170738.abstract N2 - Oasis 2 is a new main release of the Oasis web application for the detection, differential expression, and classification of small RNAs in deep sequencing data. Compared to its predecessor Oasis, Oasis 2 features a novel and speed-optimized sRNA detection module that supports the identification of small RNAs in any organism with higher accuracy. Next to the improved detection of small RNAs in a target organism, the software now also recognizes potential cross-species miRNAs and viral and bacterial sRNAs in infected samples. In addition, novel miRNAs can now be queried and visualized interactively, providing essential information for over 700 high-quality miRNA predictions across 14 organisms. Robust biomarker signatures can now be obtained using the novel enhanced classification module. Oasis 2 enables biologists and medical researchers to rapidly analyze and query small RNA deep sequencing data with improved precision, recall, and speed, in an interactive and user-friendly environment.Availability and Implementation: Oasis 2 is implemented in Java, J2EE, mysql, Python, R, PHP and JavaScript. It is freely available at http://oasis.dzne.de ER -