PT  - JOURNAL ARTICLE
AU  - Dag Alnæs
AU  - Tobias Kaufmann
AU  - Nhat Trung Doan
AU  - Aldo Córdova-Palomera
AU  - Yunpeng Wang
AU  - Francesco Bettella
AU  - Torgeir Moberget
AU  - Ole A. Andreassen
AU  - Lars T. Westlye
TI  - Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway
AID  - 10.1101/172080
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 172080
4099  - http://biorxiv.org/content/early/2017/08/03/172080.short
4100  - http://biorxiv.org/content/early/2017/08/03/172080.full
AB  - A healthy transition from adolescence to adulthood relies on a continuous individual adaptation to a dynamic environment. Here, we employed data driven multivariate approaches to derive both general cognitive and psychopathology factors as well as brain phenotypes in children and adolescents in the publicly available PNC sample. We identified a distinct brain white matter pattern which proved central for prediction of heritable cognition and psychopathology scores, highlighting the importance of fronto-temporal connections for intellectual and mental development.